A

B

FIGURE 2. A Sequence alignment of the A₁AR dual promoter region upstream of the human exons three and four compared to similiar regions in mouse and rat genomic sequences. Capital letters indicate an exon; note that mouse and rat A1adenosine receptor sequences do not have this exon. To compare with Figure 1, the alignment of all three sequences starts about 50 bp after the AP2 upstream promoter element after Promoter A. The consensus ends about 7bp after the promoter region. Gap Creation Penalty: 5. Gap Extension Penalty: 1. Wavy lines indicate the end of a particular sequence; dots indicate an inserted gap. The original total length of the alignment was from 1 to 2101. B Multiple sequence alignment dendogram of the three species.